Charles Byrnes graduated from Ilion High School in 1923. He attended the Albany College of Pharmacy and graduated in 1925. He was a partner in the Byrnes Brothers Drug Store, Syracuse with his brother Richard T. Byrnes. They were partners at the 443 James St pharmacy as early as 1932. Charles was active in politics and served on the Tenth Ward Board. Charles died on April 20, 1968 at his home at 666 W. Onondaga St., Syracuse. He was survived by his sister, Mrs Donald Mullin, and a brother Richard T. Byrnes, both of Syracuse. His funeral services were held from the Gaynor-Maslyn Funeral Home, Syracuse, and from the Cathedral of the Immaculate Conception with burial to be in St. Agnes Cemetery, Ilion.